Section 6: Anti-infective Drugs
6.1 ANTHELMINTHICS
6.1.1 INTESTINAL ANTHELMINTHICS
albendazole chewable tablet, 400 mg
levamisole tablet, 50 mg, 150 mg
(as hydrochloride)
¤mebendazole chewable tablet, 100 mg, 500 mg
niclosamide chewable tablet, 500 mg
praziquantel tablet, 150 mg, 600 mg
pyrantel chewable tablet, 250 mg
(as embonate)
oral suspension, 50 mg
(as embonate)/ml
6.1.2 ANTIFILARIALS
diethylcarbamazine tablet, 50 mg, 100 mg
(dihydrogen citrate)
ivermectin scored tablet, 3 mg, 6 mg
Complementary drug
suramin sodium (B) (2, 7) powder for injection,
1 g in vial
6.1.3 ANTISCHISTOSOMALS AND OTHER ANTITREMATODE DRUGS
praziquantel tablet, 600 mg
triclabendazole tablet, 250 mg
Complementary drug
oxamniquine (C) (8) capsule, 250 mg
syrup, 250 mg/5 ml
6.2 ANTIBACTERIALS
6.2.1 BETA LACTAM DRUGS
¤amoxicillin capsule or tablet, 250 mg,
500 mg (anhydrous)
powder for oral suspension,
125 mg (anhydrous)/5 ml
ampicillin powder for injection, 500 mg,
1 g (as sodium salt) in vial
benzathine powder for injection,
benzylpenicillin 1.44 g benzylpenicillin
(= 2.4 million IU) in 5-ml vial
benzylpenicillin powder for injection,
600 mg (= 1 million IU),
3 g (= 5 million IU)
(sodium or potassium salt) in vial
¤ Example of a therapeutic group. Various drugs can serve as
alternatives.
¤cloxacillin capsule, 500 mg, 1 g (as sodium salt)
powder for oral solution, 125 mg
(as sodium salt)/5 ml
powder for injection, 500 mg
(as sodium salt) in vial
phenoxymethylpenicillin tablet, 250 mg
(as potassium salt)
powder for oral suspension, 250 mg
(as potassium salt)/5 ml
procaine benzylpenicillin powder for injection,
1 g (= 1 million IU),
3 g (= 3 million IU) in vial
Restricted indications
¤amoxicillin + tablet, 500 mg + 125 mg
¤clavulanic acid (D)
ceftazidime (D) powder for injection, 250 mg
(as pentahydrate) in vial
¤ceftriaxone (D) powder for injection, 250 mg
(as sodium salt) in vial
imipenem + powder for injection, 250 mg
cilastatin (D) (as monohydrate) + 250 mg,
(as sodium salt)
500 mg (as monohydrate) +
500 mg in vial (as sodium salt)
6.2.2 OTHER ANTIBACTERIALS
¤chloramphenicol (7) capsule, 250 mg
oral suspension, 150 mg
(as palmitate)/5 ml
powder for injection, 1 g
(sodium succinate) in vial
¤ciprofloxacin tablet, 250 mg
(as hydrochloride)
¤doxycycline (5, 6) capsule or tablet,
100 mg (hydrochloride)
¤erythromycin capsule or tablet, 250 mg
(as stearate or ethyl succinate)
powder for oral suspension, 125 mg
(as stearate or ethyl succinate)
powder for injection, 500 mg
(as lactobionate) in vial
¤gentamicin (2, 4, 7, 11) injection, 10 mg, 40 mg
(as sulfate)/ml in 2-ml vial
¤metronidazole tablet, 200 – 500 mg
injection, 500 mg in 100-ml vial
suppository, 500 mg, 1 g
oral suspension, 200 mg
(as benzoate)/5 ml
nalidixic acid (8) tablet, 250 mg, 500 mg
nitrofurantoin (4, 8) tablet, 100 mg
spectinomycin (8) powder for injection, 2 g
(as hydrochloride) in vial
¤sulfadiazine (4) tablet, 500 mg
injection, 250 mg (sodium salt)
in 4-ml ampoule
¤sulfamethoxazole + tablet, 100 mg + 20 mg,
trimethoprim (4) 400 mg + 80 mg
oral suspension,
200 mg + 40 mg/5 ml
injection, 80 mg + 16 mg/ml
in 5-ml and 10-ml ampoule
trimethoprim (8) tablet, 100 mg, 200 mg
injection, 20 mg/ml
in 5-ml ampoule
Complementary drugs
chloramphenicol (C) oily suspension for injection,
0.5 g (as sodium succinate)/ml
in 2-ml ampoule
clindamycin (B) (8) capsule, 150 mg
injection, 150 mg
(as phosphate)/ml
Restricted indications
vancomycin (D) powder for injection 250 mg (as
hydrochloride) in vial
6.2.3 ANTILEPROSY DRUGS
clofazimine capsule, 50 mg, 100 mg
dapsone tablet, 25 mg, 50 mg, 100 mg
rifampicin capsule or tablet, 150 mg, 300 mg
6.2.4 ANTITUBERCULOSIS DRUGS
ethambutol (4) tablet, 100–400 mg
(hydrochloride)
isoniazid tablet, 100–300 mg
isoniazid + ethambutol (5) tablet, 150 mg + 400 mg
¤ Example of a therapeutic group. Various drugs can serve as
alternatives.
Essential Drugs
pyrazinamide tablet, 400 mg
rifampicin capsule or tablet, 150 mg, 300 mg
rifampicin + tablet, 60 mg + 30 mg, 150 mg + 75 mg,
isoniazid (5) 300 mg + 150 mg
tablet, 60 mg + 60 mg, 150 mg + 150 mg
(for intermittent use 3 times weekly)
rifampicin + isoniazid + tablet,
pyrazinamide (5) 60 mg + 30 mg + 150 mg,
150 mg + 75 mg + 400 mg
tablet, 150 mg + 150 mg + 500 mg
(for intermittent use 3 times weekly)
rifampicin + isoniazid + tablet, 150 mg + 75 mg +
pyrazinamide + ethambutol 400 mg + 275 mg
streptomycin (4) powder for injection,
1 g (as sulfate) in vial
Complementary drug
thioacetazone + tablet, 50 mg + 100 mg,
isoniazid (A) (5, 7) 150 mg + 300 mg
Additional reserve antituberculosis drugs for the treatment
of drug-resistant tuberculosis should be used in
specialized centres only with WHO-recommended TB
control strategy, DOTS, and treatment programmes.
6.3 ANTIFUNGAL DRUGS
amphotericin B (4) powder for injection, 50 mg in vial
¤fluconazole capsule, 50 mg
injection, 2 mg/ml in vial
oral suspension, 50 mg/5-ml
griseofulvin (7) capsule or tablet, 125 mg, 250 mg
nystatin tablet, 100 000, 500 000 IU
lozenge, 100 000 IU
pessary, 100 000 IU
Complementary drugs
flucytosine (B) (4, 8) capsule, 250 mg
infusion, 2.5 g in 250 ml
potassium iodide (A) saturated solution
6.4 ANTIVIRAL DRUGS
6.4.1 ANTIHERPES DRUGS
aciclovir (8) tablet, 200 mg
powder for injection, 250 mg
(as sodium salt) in vial
6.4.2 ANTIRETROVIRAL DRUGS
Adequate resources and specialist oversight are a
prerequisite
for the introduction of this class of drugs.
nevirapine (8) tablet, 200 mg
zidovudine (8) capsule, 100 mg, 250 mg
injection, 10 mg/ml in 20-ml vial
oral solution, 50 mg/5 ml
Drugs for treatment of HIV/AIDS include nucleoside
reverse transcriptase inhibitors (NRTIs), non-nucleoside
reverse transcriptase inhibitors (NNRTIs) and protease
inhibitors (PIs). Zidovudine and nevirapine have been
shown to reduce or prevent mother-to-child transmission
of HIV infection. This is the only indication for which
they are included here. Single
drug use with zidovudine,
except in pregnancy, is now regarded as obsolete because
of the development of resistance. Triple therapy is
beyond the budgets of most national drug programmes
and therefore HIV/AIDS treatment policies must be decided
at country or institutional level.
6.5 ANTIPROTOZOAL DRUGS
6.5.1 ANTIAMOEBIC AND ANTIGIARDIASIS
DRUGS
¤ diloxanide tablet, 500 mg (furoate)
¤metronidazole tablet, 200–500 mg
injection, 500 mg in 100-ml vial
oral suspension, 200 mg
(as benzoate)/5 ml
6.5.2 ANTILEISHMANIASIS DRUGS
¤meglumine antimoniate injection,
30%, equivalent to approx.
8.5% antimony, in 5-ml ampoule
pentamidine (5) powder for injection, 200 mg,
300 mg (isetionate) in vial
Complementary drug
amphotericin B (B) (4) powder for injection,
50 mg in vial
6.5.3 ANTIMALARIAL DRUGS
(a) FOR CURATIVE TREATMENT
¤chloroquine tablet, 100 mg, 150 mg
(as phosphate or sulfate)
syrup, 50 mg
(as phosphate or sulfate)/5 ml
injection, 40 mg (as hydrochloride,
phosphate or sulfate)/ml
in 5-ml ampoule
¤ Example of a therapeutic group. Various drugs can serve as
alternatives.
Essential Drugs
primaquine tablet, 7.5 mg, 15 mg
(as diphosphate)
¤quinine tablet, 300 mg (as bisulfate or sulfate)
injection, 300 mg (as dihydrochloride)/ml
in 2-ml ampoule
Complementary drugs
¤doxycycline (B) (for use only in capsule or tablet,
combination with quinine) 100 mg (hydrochloride)
mefloquine (B) tablet, 250 mg (as hydrochloride)
¤sulfadoxine + tablet, 500 mg + 25 mg
pyrimethamine (B)
Restricted indications
artemether (D) injection, 80 mg/ml
in 1-ml ampoule
artesunate (D) tablet, 50 mg
(b) FOR PROPHYLAXIS
chloroquine tablet, 150 mg
(as phosphate or sulfate)
syrup, 50 mg (as phosphate
or sulfate)/5 ml
doxycycline capsule or tablet,
100 mg (hydrochloride)
mefloquine tablet, 250 mg (as hydrochloride)
proguanil (for use only in tablet, 100 mg
combination with chloroquine) (hydrochloride)
6.5.4 ANTIPNEUMOCYSTOSIS AND
ANTITOXOPLASMOSIS DRUGS
pentamidine (2) tablet, 200 mg, 300 mg
pyrimethamine tablet, 25 mg
sulfamethoxazole + injection, 80 mg + 16 mg/ml
trimethoprim in 5-ml and 10-ml ampoule
6.5.5 ANTITRYPANOSOMAL DRUGS
(a) AFRICAN TRYPANOSOMIASIS
melarsoprol (2) injection, 3.6% solution
pentamidine (2) powder for injection, 200 mg,
300 mg (isetionate) in vial
suramin sodium powder for injection, 1 g in vial
Complementary drug
eflornithine (C) injection, 200 mg (hydrochloride)/
ml in 100-ml bottles
(b) AMERICAN TRYPANOSOMIASIS
benznidazole (7) tablet, 100 mg
nifurtimox (2, 8) tablet, 30 mg, 120 mg, 250 mg
6.6 INSECT REPELLENTS
diethyltoluamide topical solution, 50%, 75% |